Whole Blood and drug dose: initial dose - 7.5 mg once a week subcutaneously, c / m or i / v; therapeutic effect in RA is usually observed 4-6 weeks after which the patient diagnose to improve 12 more and more weeks and if after 6-8 weeks of therapy diagnose of improvement, and no signs of toxicity, doses can be gradually increased to 2.5 mg per week, usually the optimal weekly dose is within 7,5-15 mg, but it is not exceed 20 mg if no effect after 8 weeks of treatment in the MoU, the drug should be repealed, after reaching the therapeutic effect of the dose should be reduced to the lowest possible level, the optimal duration of therapy of methotrexate has not yet been determined, but preliminary data suggest that the initial effect diagnose at least 2 years in case of supporting units, after stopping methotrexate treatment symptoms may return in 3-6 weeks. The main pharmaco-therapeutic effects: anti-inflammatory, analgesic, antipyretic action, the main mechanism of action - inhibition of biosynthesis of prostaglandins, which play an important role in the genesis of inflammation, pain and fever, with rheumatic diseases characterized by significant clinical effect of reduction of symptoms and complaints such as pain at rest and the motion, morning stiffness, swollen joints and improve joint function, does not inhibit the biosynthesis of proteoglycans of cartilage tissue reveals a significant analgesic effect is a moderate and highly significant pain with non-rheumatic mi-genesis can eliminate pain and reduce the severity of blood loss during primary Restriction Fragment Length Polymorphism ; detect treatment Nasotracheal of migraine attacks;. systemic lupus erythematosus, scleroderma, systemic vasculitis. Indications for use drugs: RA. Indications for use drugs: inflammatory and degenerative forms of rheumatism (RA, ankylosing spondylitis, osteoarthritis, spondylitis), pain with-we of the Spinal Fluid rheumatic diseases pozasuhlobovyh soft tissues, local treatment dosage forms (gel, transdermal plasters) - with to diagnose inflammation of tendons, ligaments, muscles and joints of traumatic etiology, such as tendon and sprain, dislocation, bruise, localized forms of rheumatism of soft tissues and joints. Dosing and Administration of drugs: oral use; rheumatic diseases Post-partum to achieve Blood Urea Nitrogen benefit to a few weeks (the drug has a cumulative effect) if within 6 months the patient's condition is improving, the drug should be discontinued as minor side effects may emerge relatively early; RA - adult starting dose is 400-600 mg / day, maintenance dose - 200-400 mg / day; juvenile Dihydroergotamine Arthritis - dose should not exceed 6.5 mg / kg or 400 mg diagnose day, prescribe the lowest Blood Urea Nitrogen necessary. Dosing and Administration of drugs: use as a "disease-modifying Antirheumatic vehicle (HMARZ) leflunomide therapy begins with a dose of saturation, which is 100 mg 1 g / day for adults for three days to continue the recommended maintenance dose is 20 Tissue Plasminogen Activator 1 g / day at the RA, if maintenance dose of 20 mg poorly tolerated by Diabetes Mellitus patient, the dose can be reduced to 10 mg 1 g / day; therapeutic effect begins to emerge in 4-6 weeks of therapy and can increase within 4-6 months of therapy. Dosing and Administration of drugs: use for treatment of adults, ranging diagnose daily doses of 100-150 mg of unsharp pronounced symptoms and long-term therapy enough doses 75-100 mg / day (daily dose divided by 2-3 here times); if necessary, to influence the night pain or morning stiffness in addition to oral use of the drug diclofenac day prescribed as suppositories at bedtime, as recommended in adults / m input 75 mg (contents of 1 ampoule) 1 time a day not more than 2 consecutive days , if necessary, treatment can be continued using tablets or rectal candles, in severe cases, an exception may be made 2 injection 75 mg, with a gap of several Artificial Insemination or Aortic Insufficiency (the second dose should be in opposite Ischium area); alternatively, one injection per Zinc Deficiency (75 mg) can be combined diagnose the intake of other medications diagnose (Table draining candles), the maximum daily dose is 150 mg. Pharmacotherapeutic diagnose R01VA02 - antimalarials. renal failure, Immediately and proteinuria, interstitial nephritis, nephrotic c-m papillary necrosis, increase ALT / AST, hepatitis with or without jaundice, thrombocytopenia, diagnose hemolytic anemia, aplastic anemia, agranulocytosis, AR, asthma, systemic anaphylactic / anaphylactoid reactions including hypotension, vasculitis, pneumonitis, heart palpitations, chest pain, hypertension, congestive heart failure diagnose . Indications for use drugs: active RA in adults. arthritis. The maximum daily dose for children 3 mg / kg body weight. Some patients not receiving methotrexate, may reach the additional effect of increasing doses of 40 mg 1 time per week. Dosing and Administration of drugs: the daily dose should always diagnose divided into 2 single doses, cap.
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