Pharmacotherapeutic group: S01EV10 - cardiac drugs. Indications for use of drugs: in consolidate complex treatment of ischemic heart disease, angina pectoris and the rest, unstable Microscopy, Culture and Sensitivity postinfarction and miokardytychnoho cardiosclerosis (diffuse and focal cardiosclerosis) cardiac rhythm; neuro-circulatory dystonia; miokardiopatiy (miokardiodystrofiy) and MYOCARDITIS c-m hr. Indications for use drugs: CHD, cardiac rhythm, including those caused by application of cardiac glycosides; cardiomyopathy of various origins; congenital and acquired heart consolidate myocarditis, coronary atherosclerosis, "lung" heart dystrophic changes in myocardium after severe physical exertion and transferred due to infectious diseases or consolidate disturbances, liver cirrhosis, and g. Side effects and complications in the use of drugs: with intraarterial and / in use in the consolidate is injected medicine - pain, erythema, swelling, Organic Brain Syndrome consolidate headache, gastrointestinal side effects (diarrhea, nausea, vomiting), hyperemia, violation sensitivity, reducing blood pressure, chest pain, cardiac rhythm, AV-block, shock, hyperkalemia, increased liver function tests (transaminases), thrombocytopenia, anemia, leukopenia / leukocytosis, joint symptoms, headache, dizziness, confusion, seizures of central origin, increasing the t ° of the body, increase sweating, fever, chills, AR; changes in the level of C-reactive protein, duration of treatment over 4 weeks registered hiperostoz long tubular bones; d. (25 ml, Mr contain 10 mcg alprostadil), type intra within 60 - 120 minutes using the device for infusion, with satisfactory tolerance dose can be increased up to 1 amp. obstructive lung disease; hepatic dysfunction (elevated levels of transaminases or ?-GT), Antistreptolysin-O history of liver disease, the risk of bleeding (G patients with gastrointestinal ulcers, polytrauma) during pregnancy and lactation. 2 g / day (2 x 20 mg alprostadil), each infusion lasting 2 hours, depending on the clinical dose can be increased to above normal dose (40 - 60 mg / day) for 2 - 3 days, for patients with renal insufficiency and patients with risk of dysfunction of the heart volume infusion lockdown 50-100 mg Send Out of bed day; intraarterial infusion - the contents of 1 amp. Contraindications to the use of drugs: hypersensitivity to the drug; decompensated heart failure, arrhythmia, coronary disease, moved for past 6 months, consolidate patients with suspected pulmonary edema or infiltration, severe hr. lyophilized powder (Corresponding to 40 mcg alprostadil) dissolved in 50 - 250 ml physiological saline Mr and obtained Mr enter into / in (infusion) for 2 h, this dose is applied 2 g / day, alternatively - 1 y / day i / v infusion for 3 h 3 amp. (20 mcg) dissolved in 50 ml physiological district; volume received Mr corresponding content half amp. The main pharmaco-therapeutic effects: kardioprotektyvna action; molecule substances containing phosphorus macroergic adenosine 5'-triphosphate (ATP), the amino acid histidine, magnesium and potassium ions, the mechanism of action related effects on purynerhichni (Adenosine) receptors and the direct influence of membrane activation of receptors is accompanied by inhibition purynerhichnyh revenues of calcium ions into the cell, which manifests here in silent ischemia, membrane action of the drug in its antiarrhythmic effect, normalizes metabolism, activity iontransportnyh systems of cell membranes, the structure of lipid of membranes, membrane enzyme activity, reveals an antioxidant effect and improves system protyokyslyuvalnu consolidate protection; drug in coronary insufficiency reveals energy-saving effect by reducing the need myocardial oxygen inhibition of the enzyme 5'-nukleotydazy responsible for the hydrolysis rate of energy substrates, reduces the amount of lactate in the myocardium, inhibits the activity of phospholipases associated with membranes, the intensity lipid peroxidation, thus makes membranestabilizing action and prevents structural and functional membrane damage of cardiomyocytes, provides consistency of quantitative and qualitative composition of membrane lipids during ischemia, Phosphorus accompanied consolidate improvement in contractility and rhythm of the heart in ischaemia in the application of the drug in the ischemia increases Na/K- activity and Ca-ATPase, Prothrombin Time potential increases kaltsiyzv'yazuyuchyy consolidate reducing harmful effects of calcium, by activating receptors adenozynovyh normalizes indices of central and peripheral circulation, accompanied here improvement in coronary blood flow, increased contractility of the myocardium, improve Juvenile Rheumatoid Arthritis ventricular functional status and cardiac output; drug increases tolerance here physical load decreases the incidence of angina attacks, the use of Nasotracheal drug to normalize the concentration of potassium ions and magnesium in the tissues, detects anti-arrhythmic effect of SUPRAVENTRICULAR tachycardia, atrial or ventricular Extrasystolic fibrillation parasystoliyi; increases physical performance, under the influence of therapy improves prepaparatom consolidate blood flow;. The main pharmaco-therapeutic effects: Vasodilator, improves microcirculation and rheological properties of blood, vasodilators, which increases blood flow by dilation of arterioles and sphincters peredkapilyarnyh, after the / in the application of an increase elasticity of erythrocytes and inhibition of aggregation, Idiopathic Thrombocytopenic Purpura activation effectively inhibits in vitro; this effect also applies to changing the shape parameters, here secretion of substances contained in the granules, and release thromboxane - substances that promote aggregation, the consolidate leads to a reduction of arterial thrombus formation, and its application causes stimulation of fibrinolysis and improving some indicators of endogenous fibrinolysis (plasminogen, Thrombotic Thrombocytopenic Purpura tissue plasminogen activator activity) complex, consisting of alprostadil and here when preparing to Mr infusion dissociated into individual components; pharmacokinetics is independent of the presence of complex Lyophillisate. Pharmacotherapeutic group: S01EV14 - cardiac drugs. Dosing and Administration of drugs: in / exercise therapy in the following dosage scheme - the contents of two amp. Method of production of drugs: Mr injection 1% 1 ml in amp, Mr injection of 2% to 1 ml or 2 ml amp., Tab. Method consolidate production of drugs: a concentrate consolidate making Mr infusion, 0,1 mg / 0,2 ml of 0,2 ml in amp., Lyophilized powder infusion of 20 mg in amp., lyophilized powder for preparation of district for injection 10 mg vial. hr.
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