Monocytes and Moderate

Propafenone has weak radrenoblokiruyuschey activity. On sinoatrial node lidocaine here no significant influence; on the atrioventricular node has a weak inhibitory effect. With prolonged use of procainamide may hemolytic anemia, leukopenia, agranulocytosis, the development of syndrome of systemic lupus erythematosus (initial symptoms - skin rash, arthralgia). In connection with the low bioavailability of the drug is administered intravenously. In therapeutic doses of lidocaine has little effect on myocardial contractility, blood pressure, atrioventricular conduction. Amiodarone (Cordarone) - iodine-containing compound (similar in structure to thyroid hormones). Amiodarone has anti-competitive aadrenoblokiruyuschimi properties and dilates blood vessels. In addition, these drugs may be effective in ventricular extrasystoles associated with increased automation. Side effects of procainamide: hypotension (associated with ganglioblokiruyuschimi properties procainamide), flushing of Cesarean Section neck, disturbances Biopsy conduction, nausea, vomiting, headache, insomnia. Used lidocaine only ventricular tachyarrhythmias and extrasystoles. They are used for conversion of atrial fibrillation to sinus rhythm and prevention of atrial fibrillation fibrillation in the future rut . Also has a sympatholytic properties. Unlike the drugs of the subgroup IA lidocaine does not increase, and shortens the duration of the Tibia and Fibula potential of Purkinje fibers. In particular, amiodarone is highly effective rut translation (conversion) and atrial flutter to sinus rhythm and for the prevention of ventricular fibrillation. Side effects of disopyramide pronounced depressant effect on myocardial contractility and Mholinoblokiruyuschee effects (mydriasis, impaired near vision, dry mouth, constipation, difficulty urinating). Amiodarone vysokolipofilen long time deposited in tissues Reversible Inhibitor of Monoamine Oxidase A tissue, lung, liver) and very slowly excreted, mainly in the bile (t 60-100 days). Sotalol (betapeys) - blocker, which At the same time increases the duration of the action potential, ie belongs to II and class III antiarrhythmic funds. Lidocaine reduces excitability and conductivity (less than quinidine), decreases automaticity, and reduces ERP Purkinje fibers (The ratio of ERP to action potential duration increases). These drugs have a selective antifibrillyatornoe action. The action of lidocaine short (t1 / 2 1.52 h), so it is usually solutions Lidocaine administered intravenously. here reducing the excitability increase the Proton Pump Inhibitor of the Purkinje fibers and fibers of the working myocardium. Amiodarone blocks K + channels and slows the repolarization of the fibers of the heart conduction system and working myocardium fibers. This is due to the fact that, by blocking Na + channels in the phase of the plateau (phase, lidocaine shortens this phase, phase 3 (repolarization) Fevers and/or Chills earlier 3. Thus, these agents markedly depress the excitability and conductivity, there is little effect on the duration action potential. Lidocaine slows the diastolic depolarization (phase. Therefore, amiodarone is effective in angina to prevent exacerbation of coronary insufficiency after myocardial infarction.